The Cytotoxicity Effect Study of Fosfomycin and Mecillinam Antibiotic on Multi-Drug Resistant Klebsiella pneumoniae from Infected Urothelial Tissue

Enterobacteriaceae bacteria are clinically important and lead to various diseases associated with high mortality morbidity, including urinary tract infections, yet their treatment is a challenge due increasing antibiotic resistance. This study examined the cytotoxicity effects viability-inducing abilities of mecillinam fosfomycin antibiotics in extended-spectrum beta-lactamase Klebsiella pneumoniae strain. The immortalized normal human urothelial cell line was used using cultures were prepared. bacterial association assays then conducted. cytotoxic pneumoniae, cefotaxime-Munich, ampicillinase C, oxacillinase transmission electron microscopy on line. measured by lactate dehydrogenase, death marker visualized hematoxylin. strains showed significantly reduced cells than cefotaxime-Munich strains. C had higher indicated that all increased after 24 or 12 h incubation. Antibiotic resistance have genes encoding resistance, such as oxacillinase.